Do you take your arthritis med with fruit Juice?
If yes, think again. Fruit juice may not let you achieve remission…..
And why is that So?
Many fruits, especially grapefruit juice & possibly orange, starfish, Seville apple juice affect the absorption of methotrexate from the intestine.
Methotrexate is absorbed in the intestine by a pump called OATP. These juices contain chemicals that block this pump & decrease absorption of methotrexate. Grapefruit also blocks CY 350 which affects other meds.
So now that we know about this, what can we do?
1) Avoid taking methotrexate with any fruit juice.
2) Keep a gap of at least 2 hours between methotrexate fruit & any fruit juice.
Arthritis support board 
Interesting! Who would have thought of that!
What about fibromyalgia? Does an increased intake of orange and apple affect the effect of our medications too?
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Thanks a lot Dr. for update, which is very useful.
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For arthritis sufferers, you may want to consider Yucca as a natural treatment. It is a proven medical fact that the extract from Yucca helps to ease the pain of arthritis. You can buy Yucca at most grocery stores, or get the extract from stores that sell vitamins and supplements.
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Thanks for this info, Doc! Never thought that fruit juices affect w/ #rheum meds…Are there other drinks that we need to take note of when taking #rheum meds? Again, thank you! 🙂
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Not really.
Grapefruit juice is the one that interacts with methotrexate.
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Very interesting! I take lemon juice (with real lemons) right after each methotrexate injection. It helps with the metalic taste in my mouth. Would lemon juice effect methotrexate ?
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